Mango leaves contain several beneficial plant compounds, including polyphenols and terpenoids.
Terpenoids are important for optimal vision and immune health. They’re also antioxidants, which protect your cells from harmful molecules called free radicals.
Meanwhile, polyphenols have antioxidant and anti-inflammatory properties. Some research suggests that they improve gut bacteria and help treat or prevent conditions like obesity, diabetes, heart disease, and cancer.
Mangiferin, a polyphenol found in many plants but in especially high amounts in mango and mango leaves, is credited with numerous benefits.
Studies have investigated it as an anti-microbial agent and potential treatment for tumors, diabetes, heart disease, and fat digestion abnormalities.
Many of the potential benefits of mango leaves result from anti-inflammatory properties.
While inflammation is part of your body’s normal immune response, chronic inflammation can increase your risk of various diseases.
Animal studies suggest that mango leaves’ anti-inflammatory properties may even protect your brain from conditions like Alzheimer’s or Parkinson’s.
In one study, mango leaf extract given to rats at 2.3 mg per pound of body weight (5 mg per kg) helped counteract artificially induced oxidative and inflammatory biomarkers in the brain.
Mango leaf extract may help manage obesity, diabetes, and metabolic syndrome by interfering with fat metabolism.
Multiple animal studies have found that mango leaf extract inhibits fat accumulation in tissue cells. Another study in mice shows that cells treated with a mango leaf extract had lower levels of fat deposits and higher levels of adiponectin.
In a study in rats with obesity, those fed mango leaf tea in addition to a high fat diet gained less abdominal fat than those given only the high fat diet.
In a 12-week study in 97 adults with excess weight, those given 150 mg of mangiferin daily had lower fat levels in their blood and scored significantly better on an insulin resistance index than did those given a placebo.
Lower insulin resistance suggests improved diabetes management.
Mango leaf may help manage diabetes due to its effects on fat metabolism.
Elevated triglycerides levels are often associated with insulin resistance and type 2 diabetes.
One study gave mango leaf extract to mice. After 2 weeks, they showed significantly lower triglyceride and blood sugar levels.
A study in rats found that administering 45 mg per pound of body weight (100 mg per kg) of mango leaf extract reduced hyperlipidemia, a condition marked by unusually high levels of triglycerides and cholesterol.
In a study that compared mango leaf extract and the oral diabetes drug glibenclamide in rats with diabetes, those given the extract had significantly lower blood sugar levels than the glibenclamide group after 2 weeks.
Test-tube studies suggest specific effects against leukemia and lung, brain, breast, cervix, and prostate cancers.
What’s more, mango leaves exhibits strong anticancer potential due to its lignans, which are another type of polyphenol. Keep in mind that these results are preliminary and that mango leaves should not be considered a cancer treatment.
A study in rodents found that orally administering mango leaf extract at 113–454 mg per pound (250–1,000 mg per kg) of body weight decreased the number of stomach lesions.
Another rodent study found similar results, with mangiferin significantly improving digestive damage.
Mango leaf extract may reduce signs of skin aging due to its antioxidant content.
Keep in mind that this extract was a general mango extract, not one specific to mango leaves.
Mangiferin has also been studied for psoriasis, a skin condition that causes itchy, dry patches. A test-tube study using human skin confirmed that this polyphenol encouraged wound healing.
Yet, there’s little scientific evidence to support these claims.